Research Paper Volume 13, Issue 4 pp 5986—6009

Overexpression of hsa_circ_0002874 promotes resistance of non-small cell lung cancer to paclitaxel by modulating miR-1273f/MDM2/p53 pathway

Effect of agomir-1273f and siRNAs-ciR on tumor growth in drug-resistant xenograft model. (A) The gross morphology of tumors measured on day 10 after injecting agomir-1273f plus PTX, siRNAs-ciR plus PTX or PTX. (B) Growth curves of subcutaneous xenograft tumors. Tumor volumes were calculated as length × (square of width) /2. (C–E) qPCR analysis was performed to detect the expression of hsa

Figure 6. Effect of agomir-1273f and siRNAs-ciR on tumor growth in drug-resistant xenograft model. (A) The gross morphology of tumors measured on day 10 after injecting agomir-1273f plus PTX, siRNAs-ciR plus PTX or PTX. (B) Growth curves of subcutaneous xenograft tumors. Tumor volumes were calculated as length × (square of width) /2. (CE) qPCR analysis was performed to detect the expression of hsa_circ_0002874, miR-1273f, and MDM2. BL, baseline tumor volume. *p <0.05, **p <0.01, n=4 in each group.