Research Paper Volume 13, Issue 4 pp 5986—6009

Overexpression of hsa_circ_0002874 promotes resistance of non-small cell lung cancer to paclitaxel by modulating miR-1273f/MDM2/p53 pathway

Levels of hsa

Figure 7. Levels of hsa_circ_0002874, miR1273f, and MDM2 in samples of NSCLC tissues and paired non-cancerous matched tissues. (AC) Levels of hsa_circ_0002874, miR1273f, and MDM2 were measured using qPCR compared with GAPDH/U6 and calculated using the equation 2-ΔΔCT. (DF) Schematic representation of the expression level of hsa_circ_0002874, miR1273f, and MDM2 in 20 NSCLC tissues compared with paired non-cancerous matched tissues. (G) Correlation analysis between hsa_circ_0002874 expression and miR1273f expression via Spearman Rank test. (H) Correlation analysis between hsa_circ_0002874 expression and MDM2 expression via Spearman Rank test. (I) Correlation analysis between miR1273f expression and MDM2 expression via Spearman Rank test. (J) Analysis of MDM2 expression in different pathological types of NSCLC via Oncomine database. (K) Heat map of the relative expression of hsa_circ_0002874, miR1273f, and MDM2 in 20 patients.