Research Paper Volume 13, Issue 4 pp 5986—6009

Overexpression of hsa_circ_0002874 promotes resistance of non-small cell lung cancer to paclitaxel by modulating miR-1273f/MDM2/p53 pathway

Levels of MDM2 and P53 protein in samples of NSCLC tissues and paired non-cancerous matched tissues. (A) MDM2 and P53 expression in 20 NSCLC tissues compared with paired non-cancerous matched tissues were determined by western blot. (B) The quantification of MDM2 protein was analyzed according to bands in Figure 8A. (C) The quantification of P53 protein was analyzed according to bands in Figure 8A. (D, E) Schematic representation of the expression level of MDM2 and P53 in 20 NSCLC tissues compared with paired non-cancerous matched tissues. (F) Correlation analysis between MDM2 expression and P53 expression via Spearman Rank test.

Figure 8. Levels of MDM2 and P53 protein in samples of NSCLC tissues and paired non-cancerous matched tissues. (A) MDM2 and P53 expression in 20 NSCLC tissues compared with paired non-cancerous matched tissues were determined by western blot. (B) The quantification of MDM2 protein was analyzed according to bands in Figure 8A. (C) The quantification of P53 protein was analyzed according to bands in Figure 8A. (D, E) Schematic representation of the expression level of MDM2 and P53 in 20 NSCLC tissues compared with paired non-cancerous matched tissues. (F) Correlation analysis between MDM2 expression and P53 expression via Spearman Rank test.