Figure 1. Indoxyl sulfate administration caused indoxyl sulfate serum accumulation in unilateral nephrectomized mice. The intact and unilateral nephrectomized (1/2-Nephrectomy) mice were intraperitoneally injected with various doses of indoxyl sulfate (IS) for 7 weeks. The blood was collected and subjected to the measurement of indoxyl sulfate (A), BUN (B), and creatinine (C). *p < 0.05 vs. intact control group without indoxyl sulfate, n = 5.