Research Paper Volume 13, Issue 5 pp 6681—6701

Indoxyl sulfate caused behavioral abnormality and neurodegeneration in mice with unilateral nephrectomy

Indoxyl sulfate administration caused indoxyl sulfate serum accumulation in unilateral nephrectomized mice. The intact and unilateral nephrectomized (1/2-Nephrectomy) mice were intraperitoneally injected with various doses of indoxyl sulfate (IS) for 7 weeks. The blood was collected and subjected to the measurement of indoxyl sulfate (A), BUN (B), and creatinine (C). *p

Figure 1. Indoxyl sulfate administration caused indoxyl sulfate serum accumulation in unilateral nephrectomized mice. The intact and unilateral nephrectomized (1/2-Nephrectomy) mice were intraperitoneally injected with various doses of indoxyl sulfate (IS) for 7 weeks. The blood was collected and subjected to the measurement of indoxyl sulfate (A), BUN (B), and creatinine (C). *p < 0.05 vs. intact control group without indoxyl sulfate, n = 5.