Figure 8. Schematic diagram regarding how GH reverses the age-associated depletion of ovarian reserve and declining quality of oocytes. In old mice, the ovarian reserve and the levels of GH are declined. The decreased GH enhances the expression levels of Fos and Jun family which increase the oocyte apoptosis and DNA damage. Administration of GH restores the depletion of ovarian reserve and induces the increment of GHRs. Additionally, GH supplementation exerts an influence on reversing apoptosis via lowering the expression of Fos and Jun which improves the oocyte quality.