Research Paper Volume 13, Issue 4 pp 6041—6054

Long non-coding RNA CERS6-AS1 facilitates the oncogenicity of pancreatic ductal adenocarcinoma by regulating the microRNA-15a-5p/FGFR1 axis

CERS6-AS1 knockdown impairs the tumor growth of PDAC cells in vivo. (A) Tumor growth was monitored by measuring tumor volumes in 6-day intervals. (B) Representative images of tumor xenografts obtained from the sh-CERS6-AS1 and sh-NC groups. (C) The tumor xenografts removed from mice at 30 days after the injection of SW1990 cells stably overexpressing sh-CERS6-AS1 or sh-NC. The weights of xenografts were detected. (D) The level of CERS6-AS1 in xenografts was evaluated by RT-qPCR. (E) miR-15a-5p expression in the xenografts was determined by RT-qPCR. (F) Western blotting was used to measure FGFR1 protein expression in xenografts. **P

Figure 8. CERS6-AS1 knockdown impairs the tumor growth of PDAC cells in vivo. (A) Tumor growth was monitored by measuring tumor volumes in 6-day intervals. (B) Representative images of tumor xenografts obtained from the sh-CERS6-AS1 and sh-NC groups. (C) The tumor xenografts removed from mice at 30 days after the injection of SW1990 cells stably overexpressing sh-CERS6-AS1 or sh-NC. The weights of xenografts were detected. (D) The level of CERS6-AS1 in xenografts was evaluated by RT-qPCR. (E) miR-15a-5p expression in the xenografts was determined by RT-qPCR. (F) Western blotting was used to measure FGFR1 protein expression in xenografts. **P < 0.01.