Research Paper Volume 13, Issue 3 pp 3218—3238

Brain microstructure mediates sex-specific patterns of cognitive aging

Sex-stratified associations between cortical gray matter microstructure and cognitive function. Partial correlations between RSI metrics and cognitive test scores, adjusted for education, are shown for women (A) and men (B). Warm colors indicate positive correlations and cool colors indicate negative correlations (r>0.30). For Trails B, lower scores indicate better performance. (HI, hindered isotropic; IF, isotropic free water; ND, neurite density; RI, restricted isotropic).

Figure 1. Sex-stratified associations between cortical gray matter microstructure and cognitive function. Partial correlations between RSI metrics and cognitive test scores, adjusted for education, are shown for women (A) and men (B). Warm colors indicate positive correlations and cool colors indicate negative correlations (r>0.30). For Trails B, lower scores indicate better performance. (HI, hindered isotropic; IF, isotropic free water; ND, neurite density; RI, restricted isotropic).