Research Paper Volume 13, Issue 5 pp 7120—7132

Hypoxic pancreatic stellate cell-derived exosomal mirnas promote proliferation and invasion of pancreatic cancer through the PTEN/AKT pathway

Hypoxic PSC-derived exosomal miR-4465 and miR-616-3p promote migration and invasion in PC cells. PANC-1 and MIA PaCa-2 cells were treated with exosomes secreted from hypoxic and normoxic PSCs. EV-depleted complete medium was used as control. (A) Results of wound-healing migration assays (magnification: 40×). (B) Results of Transwell invasion assays (magnification: 40×). *P

Figure 3. Hypoxic PSC-derived exosomal miR-4465 and miR-616-3p promote migration and invasion in PC cells. PANC-1 and MIA PaCa-2 cells were treated with exosomes secreted from hypoxic and normoxic PSCs. EV-depleted complete medium was used as control. (A) Results of wound-healing migration assays (magnification: 40×). (B) Results of Transwell invasion assays (magnification: 40×). *P<0.05; **P<0.01.