Research Paper Volume 13, Issue 5 pp 7120—7132

Hypoxic pancreatic stellate cell-derived exosomal mirnas promote proliferation and invasion of pancreatic cancer through the PTEN/AKT pathway

miR-4465 and miR-616-3p overexpression enhances PC cell proliferation, migration, and invasion. PANC-1 and MIA PaCa-2 were transfected with miR-4465, miR-616-3p, or negative control (NC) mimics. (A) CCK-8 proliferation assay results. (B) Wound-healing migration assay results. (C) Transwell invasion assay results. *P

Figure 4. miR-4465 and miR-616-3p overexpression enhances PC cell proliferation, migration, and invasion. PANC-1 and MIA PaCa-2 were transfected with miR-4465, miR-616-3p, or negative control (NC) mimics. (A) CCK-8 proliferation assay results. (B) Wound-healing migration assay results. (C) Transwell invasion assay results. *P<0.05; **P<0.01.