Research Paper Volume 13, Issue 5 pp 7314—7329

Levodopa affects spike and local field synchronisation in the pedunculopontine nucleus of a rat model of Parkinson’s disease

Spike-field coherence (SFC) in the pedunculopontine nucleus (PPN) and local field potential (LFP). (A) Frequency-SFC plots in resting Type A neurones. (B) Frequency-SFC plots in resting Type B neurones. (C) Statistical results of SFC obtained with resting Type A neurones. (D) Statistical results of SFC obtained with resting Type B neurones. (E) Frequency-SFC plots in Type A neurones of rats in locomotion state. (F) Frequency-SFC plots in Type B neurones of rats in locomotion state. (G) Statistical results of SFC obtained with Type A neurones of rats in locomotion state. (H) Statistical results of SFC obtained with Type B neurones of rats in locomotion state. The frequency bands with significant changes are highlighted via blue boxes. ***p

Figure 5. Spike-field coherence (SFC) in the pedunculopontine nucleus (PPN) and local field potential (LFP). (A) Frequency-SFC plots in resting Type A neurones. (B) Frequency-SFC plots in resting Type B neurones. (C) Statistical results of SFC obtained with resting Type A neurones. (D) Statistical results of SFC obtained with resting Type B neurones. (E) Frequency-SFC plots in Type A neurones of rats in locomotion state. (F) Frequency-SFC plots in Type B neurones of rats in locomotion state. (G) Statistical results of SFC obtained with Type A neurones of rats in locomotion state. (H) Statistical results of SFC obtained with Type B neurones of rats in locomotion state. The frequency bands with significant changes are highlighted via blue boxes. ***p < 0.001, *p < 0.05, relative to the control group; ###p < 0.001, ##p < 0.01, #p < 0.05, relative to the lesioned group.