Figure 4. Overexpression of circ_0000527 promoted secretion of inflammatory mediators. (A) The elevated expression of circ_0000527 induced IL-1β expression in MG-63 cells. (B) The expression of IL-6 was determined using an ELISA assay. (C) The ectopic expression of circ_0000527 enhanced IL-8 expression. (D) The expression of TNF-α was determined by ELISA assay. ***p<0.001.