Research Paper Volume 13, Issue 4 pp 6091—6102

Circ_0000527 promotes osteosarcoma cell progression through modulating miR-646/ARL2 axis

Ectopic expression of circ

Figure 9. Ectopic expression of circ_0000527 promoted cell growth, cycle and invasion via modulating ARL2. (A) The expression of ARL2 was determined using qRT-PCR assay. (B) The expression of ki-67 was detected using qRT-PCR analysis. (C) The level of CDK2 was measured by qRT-PCR assay. (D) Inhibition expression of ARL2 suppressed cell proliferation in circ_0000527-overexpressing MG-63 cell. (E) Cell cycle was determined by flow cytometry. *p<0.05,** p<0.01, ***p<0.001.