Research Paper Volume 13, Issue 5 pp 7430—7453

Potential role of glucosamine-phosphate N-acetyltransferase 1 in the development of lung adenocarcinoma

Genomic alterations of GNPNAT1 in LUAD (cBioPortal).GNPNAT1 alterations in the LUAD cohort. The different types of genetic alterations highlighted in different colors. (A) There were 39 out of 522 (7.47%) LUAD patients with GNPNAT1 alterations. (B) GNPNAT1 CNV frequency distribution in different stage subgroups. (C) GNPNAT1 CNV affected OS in LUAD. (D) The volcano plot shows genes co-occurring with GNPNAT1 amplification. (E) The bar plot shows the top 10 GNPNAT1 co-occurrent alteration genes. (F) KEGG pathway analysis of significant GNPNAT1 co-occurrent genes. (G) GO

Figure 5. Genomic alterations of GNPNAT1 in LUAD (cBioPortal).GNPNAT1 alterations in the LUAD cohort. The different types of genetic alterations highlighted in different colors. (A) There were 39 out of 522 (7.47%) LUAD patients with GNPNAT1 alterations. (B) GNPNAT1 CNV frequency distribution in different stage subgroups. (C) GNPNAT1 CNV affected OS in LUAD. (D) The volcano plot shows genes co-occurring with GNPNAT1 amplification. (E) The bar plot shows the top 10 GNPNAT1 co-occurrent alteration genes. (F) KEGG pathway analysis of significant GNPNAT1 co-occurrent genes. (G) GO_BP terms of significantly GNPNAT1 co-occurrent genes. (H) The lung-specific PPI network of significant GNPNAT1 co-occurrent genes. (I) Transcription factor-miRNA (TF-miRNA) coregulatory network of significant GNPNAT1 co-occurrent genes.