Research Paper Volume 13, Issue 3 pp 3269—3289

Geroprotective effects of Alzheimer’s disease drug candidates

J147 and CMS121 administration extend lifespan in D. melanogaster. (A) Chemical structures of CMS121 and J147. (B) 2 μM J147 increased longevity in male Drosophila by 12.8% (p = 0.0002). The data in panel 1B is redrawn from Goldberg et al. [19]. (C) 5 μM CMS121 increased longevity in male Drosophila by 8.46% (p = 0.017). Results were compared by Student’s t-test.

Figure 1. J147 and CMS121 administration extend lifespan in D. melanogaster. (A) Chemical structures of CMS121 and J147. (B) 2 μM J147 increased longevity in male Drosophila by 12.8% (p = 0.0002). The data in panel 1B is redrawn from Goldberg et al. [19]. (C) 5 μM CMS121 increased longevity in male Drosophila by 8.46% (p = 0.017). Results were compared by Student’s t-test.