Research Paper Volume 13, Issue 3 pp 3269—3289

Geroprotective effects of Alzheimer’s disease drug candidates

J147 and CMS121 improve markers for brain and kidney health in old SAMP8 mice. (A) Bar graph of time spent in the open arms of the elevated plus maze (n= 11-18/group). The data in panel 1A is redrawn from Currais et al. [26]. (B) Bar graph of measured kidney weights (n = 6/group). (C) Bar graph of measured plasma creatinine levels (n = 6/group). Data are presented as mean ± SEM. Results were compared by one-way ANOVA, followed by Turkey’s multiple comparison test.

Figure 2. J147 and CMS121 improve markers for brain and kidney health in old SAMP8 mice. (A) Bar graph of time spent in the open arms of the elevated plus maze (n= 11-18/group). The data in panel 1A is redrawn from Currais et al. [26]. (B) Bar graph of measured kidney weights (n = 6/group). (C) Bar graph of measured plasma creatinine levels (n = 6/group). Data are presented as mean ± SEM. Results were compared by one-way ANOVA, followed by Turkey’s multiple comparison test.