Research Paper Volume 13, Issue 6 pp 8454—8466

Endogenous conversion of n-6 to n-3 polyunsaturated fatty acids facilitates the repair of cardiotoxin-induced skeletal muscle injury in fat-1 mice

Fat-1 mice expressed the fat-1 gene and had high levels of n-3 PUFAs and low n-6: n-3 ratio. (A) Genotyping results of fat-1 gene in fat-1 and wild-type littermates. (B) The lipid composition including n-6 and n-3 PUFA levels and n-6/n-3 PUFA ratio in the tail and gastrocnemius muscle tissues of fat-1 and wild-type mice. Data were expressed as the percentage of total fatty acids ± SD. ***P

Figure 1. Fat-1 mice expressed the fat-1 gene and had high levels of n-3 PUFAs and low n-6: n-3 ratio. (A) Genotyping results of fat-1 gene in fat-1 and wild-type littermates. (B) The lipid composition including n-6 and n-3 PUFA levels and n-6/n-3 PUFA ratio in the tail and gastrocnemius muscle tissues of fat-1 and wild-type mice. Data were expressed as the percentage of total fatty acids ± SD. ***P < 0.001 vs. WT.