Priority Research Paper Volume 13, Issue 4 pp 4747—4777

Insights into epithelial cell senescence from transcriptome and secretome analysis of human oral keratinocytes

NOK senescence displays important distinguishing characteristics. (A) Mass spectrometry analysis of proposed SASP additions. Selected proteins significantly increased in EV pellet or CM (Mean ± SD). Y-axis scales differ. (B) mRNA levels of proposed SASP additions. (Mean ± SD). Y-axis scales differ. (C) TEM of vesicles from EV pellet labelling for surface HSP60 (left, and 4x enlargement, right). For Figure 6A, 6B, *p

Figure 6. NOK senescence displays important distinguishing characteristics. (A) Mass spectrometry analysis of proposed SASP additions. Selected proteins significantly increased in EV pellet or CM (Mean ± SD). Y-axis scales differ. (B) mRNA levels of proposed SASP additions. (Mean ± SD). Y-axis scales differ. (C) TEM of vesicles from EV pellet labelling for surface HSP60 (left, and 4x enlargement, right). For Figure 6A, 6B, *p<0.05, **p<0.01, ***p<0.001, **** p<0.0001.