Research Paper Volume 13, Issue 5 pp 7644—7659

Platelets transport β-amyloid from the peripheral blood into the brain by destroying the blood-brain barrier to accelerate the process of Alzheimer's disease in mouse models

Aβ levels in platelets and hippocampi from SAMP8 mice of different ages. (A) Aβ1-40 contents in platelets and hippocampi from 6- and 10-month-old SAMP8 mice. (B) Aβ1-42 contents in platelets and hippocampi from 6- and 10-month-old SAMP8 mice. (C) Aβ1-40 contents in platelets and hippocampi from 6- and 10-month-old APP/PS1 mice. (D) Aβ1-42 contents in platelets and hippocampi from 6- and 10-month-old APP/PS1 mice. Each group included 5 mice, ***P

Figure 2. Aβ levels in platelets and hippocampi from SAMP8 mice of different ages. (A) Aβ1-40 contents in platelets and hippocampi from 6- and 10-month-old SAMP8 mice. (B) Aβ1-42 contents in platelets and hippocampi from 6- and 10-month-old SAMP8 mice. (C) Aβ1-40 contents in platelets and hippocampi from 6- and 10-month-old APP/PS1 mice. (D) Aβ1-42 contents in platelets and hippocampi from 6- and 10-month-old APP/PS1 mice. Each group included 5 mice, ***P<0.001 compared with the 6-month-old mice.