Research Paper Volume 13, Issue 5 pp 7644—7659

Platelets transport β-amyloid from the peripheral blood into the brain by destroying the blood-brain barrier to accelerate the process of Alzheimer's disease in mouse models

Effects of intragastric administration of ASA on learning and memory ability and AD related indexes of blood and brain tissue in mice. (A) Latency (escape latency), the time mice spent finding the underwater hidden platform in the MWM on training days. (B) Track trail, mice track trail during the probe trial on the last day. (C) Crossing times, the number of times the mice crossed the former platform area during the probe trial on the last day. (D) Time spent in the target quadrant. n=6 in the SAMR1+ddH2O and SAMR1+ASA groups; n=10 in the SAMP8+ddH2O and SAMR1+ASA groups. *P2O group and #PE) The quantity and volume of platelets. (F) Aβ1-40, Aβ1-42 and tau protein levels per unit of platelets. (G) Aβ1-40, Aβ1-42 and tau protein levels in platelets. (H) Aβ1-40, Aβ1-42 and tau protein levels in plasma. (I) Aβ1-40, Aβ1-42 and tau protein levels in the hippocampus. (J) Aβ1-40, Aβ1-42 and tau protein levels in the cortex. *P**P2O group.

Figure 5. Effects of intragastric administration of ASA on learning and memory ability and AD related indexes of blood and brain tissue in mice. (A) Latency (escape latency), the time mice spent finding the underwater hidden platform in the MWM on training days. (B) Track trail, mice track trail during the probe trial on the last day. (C) Crossing times, the number of times the mice crossed the former platform area during the probe trial on the last day. (D) Time spent in the target quadrant. n=6 in the SAMR1+ddH2O and SAMR1+ASA groups; n=10 in the SAMP8+ddH2O and SAMR1+ASA groups. *P<0.05 compared with the SAMR1+ddH2O group and #P<0.05 compared with the SAMR1+ASA group. (E) The quantity and volume of platelets. (F) Aβ1-40, Aβ1-42 and tau protein levels per unit of platelets. (G) Aβ1-40, Aβ1-42 and tau protein levels in platelets. (H) Aβ1-40, Aβ1-42 and tau protein levels in plasma. (I) Aβ1-40, Aβ1-42 and tau protein levels in the hippocampus. (J) Aβ1-40, Aβ1-42 and tau protein levels in the cortex. *P<0.05 and **P<0.01 compared with the SAMP8+ddH2O group.