Research Paper Volume 13, Issue 7 pp 9542—9565

Gastrodin ameliorates learning and memory impairment in rats with vascular dementia by promoting autophagy flux via inhibition of the Ca2+/CaMKII signal pathway

A schematic diagram of the possible mechanism of gastrodin improving cognitive impairment in vascular dementia rats by promoting autophagy flux through inhibiting Ca2+/CaMKII signal pathway. GAS improves cognitive dysfunction in a VD rat model. GAS ameliorates the CoCl2-induced suppression of autophagic flux by lowering [Ca2+]i-dependent CaMKII phosphorylation in HT22 cells, reduces apoptosis in HT22 cells.

Figure 7. A schematic diagram of the possible mechanism of gastrodin improving cognitive impairment in vascular dementia rats by promoting autophagy flux through inhibiting Ca2+/CaMKII signal pathway. GAS improves cognitive dysfunction in a VD rat model. GAS ameliorates the CoCl2-induced suppression of autophagic flux by lowering [Ca2+]i-dependent CaMKII phosphorylation in HT22 cells, reduces apoptosis in HT22 cells.