Research Paper Volume 13, Issue 6 pp 8720—8736

Parvalbumin interneuron-mediated neural disruption in an animal model of postintensive care syndrome: prevention by fluoxetine

Abnormal behavioral outcomes induced by combined stress were reversed by fluoxetine treatment. (A) Schematic timeline of the experimental procedure. (B) There was no difference in time spent in the center in the open arena among groups. (C) Combined stress significantly increased distance travelled compared with control group, which was prevented by fluoxetine treatment. (D) Mice in LS group displayed significantly decreased spontaneous alteration than that in control group, which was reversed by fluoxetine treatment. (E) Combined stress induced significantly decreased time with the novel object, which was prevented by fluoxetine treatment. (F) Combined stress induced significantly decreased recognition ratio was not prevented by fluoxetine treatment. (G) Combined stress induced significantly decreased preference for sucrose was prevented by fluoxetine treatment. Data are shown as mean ± SEM (n = 12), *P #P

Figure 6. Abnormal behavioral outcomes induced by combined stress were reversed by fluoxetine treatment. (A) Schematic timeline of the experimental procedure. (B) There was no difference in time spent in the center in the open arena among groups. (C) Combined stress significantly increased distance travelled compared with control group, which was prevented by fluoxetine treatment. (D) Mice in LS group displayed significantly decreased spontaneous alteration than that in control group, which was reversed by fluoxetine treatment. (E) Combined stress induced significantly decreased time with the novel object, which was prevented by fluoxetine treatment. (F) Combined stress induced significantly decreased recognition ratio was not prevented by fluoxetine treatment. (G) Combined stress induced significantly decreased preference for sucrose was prevented by fluoxetine treatment. Data are shown as mean ± SEM (n = 12), *P < 0.05 vs control group, #P < 0.05 vs LS group. Con, control; LPS, lipopolysaccharide; Flu, fluoxetine; LS, LPS + stress.