Research Paper Volume 13, Issue 6 pp 8797—8816

Functional predication of differentially expressed circRNAs/lncRNAs in the prefrontal cortex of Nrf2-knockout mice

Predicted functions of the DEcircRNAs/DElncRNAs involved in the DEcircRNA/DElncRNA-miRNA-DEmRNA network. (A, B) The top 30 most significantly enriched GO (A) and KEGG (B) pathways of the DEmRNAs that were targets of the five DEcircRNAs (mmu

Figure 4. Predicted functions of the DEcircRNAs/DElncRNAs involved in the DEcircRNA/DElncRNA-miRNA-DEmRNA network. (A, B) The top 30 most significantly enriched GO (A) and KEGG (B) pathways of the DEmRNAs that were targets of the five DEcircRNAs (mmu_circ_0000233, mmu_circ_0015035, mmu_circ_0012936, mmu_circ_0008393 and cicRNA.20127) and seven DElncRNAs (NONMMUT132168, NONMMUT127961, NONMMUT132160, ENSMUST00000204847, NONMMUT024778, NONMMUT109267 and ENSMUST00000194077). The X-axis displays the enrich factor in the GO and KEGG pathways and the Y-axis displays the GO and KEGG pathways. The color scale depicts the p-values. The sizes of the nodes represent the counts of genes enriched in the GO and KEGG pathways. (C, D) Diagram of the various functions of the DEcircRNAs/DElncRNAs.