Research Paper Volume 13, Issue 7 pp 9582—9591

LCZ696 ameliorates lipopolysaccharide-induced endothelial injury

LCZ696 reduced LPS-induced expression and production of chemokines MCP-1 and CXCL1 in HUVECs

Figure 5. LCZ696 reduced LPS-induced expression and production of chemokines MCP-1 and CXCL1 in HUVECs. Cells were stimulated with LPS (1 μg/mL) in the presence or absence of LCZ696 (10, 20 μM) for 24 hours. (A). mRNA of MCP-1; (B). mRNA of CXCL1; (C). Secretions of MCP-1; (D). Secretions of CXCL1 (***P < 0.005 vs. control group; ##, ###P < 0.01, 0.005 vs. LPS group).