Figure 8. LCZ696 suppresses LPS-induced activation of the TLR4/Myd88 pathway in HUVECs. Cells were stimulated with LPS (1 μg/mL) in the presence or absence of LCZ696 (20 μM) for 24 hours. (A). The levels of TLR4 and Myd88 were measured using Western blot; (B). Nuclear levels of NF-κB p65 (***P < 0.005 vs. control group; ##, ###P < 0.01, 0.005 vs. LPS group).