Research Paper Volume 13, Issue 4 pp 4850—4880

Metabolic footprint of aging and obesity in red blood cells

OPLS-DA analysis of the metabolomic profile of RBCs of BMI-1 (BMI (A) Score plot of the OPLS-DA model obtained. R2Y(cum)=0.75, Q2(cum)=0.413. Permutation test result: R2=(0.0, 0.248), Q2=(0.0, -0.362). CV-Anova: p-value=0.000016. (B) S-plot showing the most important metabolites contributing to the discrimination between non-obese and obese subjects. G1P: glucose 1-phoshate, 2,3BPG: 2,3-biphosphoglycerate.

Figure 4. OPLS-DA analysis of the metabolomic profile of RBCs of BMI-1 (BMI<30) and BMI-2 (BMI≥30) groups. (A) Score plot of the OPLS-DA model obtained. R2Y(cum)=0.75, Q2(cum)=0.413. Permutation test result: R2=(0.0, 0.248), Q2=(0.0, -0.362). CV-Anova: p-value=0.000016. (B) S-plot showing the most important metabolites contributing to the discrimination between non-obese and obese subjects. G1P: glucose 1-phoshate, 2,3BPG: 2,3-biphosphoglycerate.