Figure 2. miR-21 ISH. Visual assessment of miR-21 expression (blue stain) in the rectal mucosa of 4 representative pediatric and adult UC patients. The miR-21 ISH signal is observed in relation to crypt abscesses. The miRNA expression by proportion of the region of interest: pediatric de novo diagnosed=0.079; pediatric previously diagnosed =0.023; adult de novo diagnosed=0.016; adult previously diagnosed=0.032. Sections were counterstained with nuclear fast red.