Research Paper Volume 13, Issue 6 pp 8960—8974

Exercise in mice ameliorates high-fat diet-induced nonalcoholic fatty liver disease by lowering HMGCS2

Exercise prevented hepatic injury and fibrosis in HFD-fed mice. Quantification of mRNA for (A) CD36, (B) FAS, and (C) PPAR-α. (D) Representative western blot for PPAR-α from at least 3 different cultures, (E) Quantification of PPAR-αprotein levels relative to GAPDH. (F) Representative picrosirius red staining for collagen deposition (red color). (G) Quantification for total collagen deposition. Data are presented as mean ± SD, n = 6. * P

Figure 5. Exercise prevented hepatic injury and fibrosis in HFD-fed mice. Quantification of mRNA for (A) CD36, (B) FAS, and (C) PPAR-α. (D) Representative western blot for PPAR-α from at least 3 different cultures, (E) Quantification of PPAR-αprotein levels relative to GAPDH. (F) Representative picrosirius red staining for collagen deposition (red color). (G) Quantification for total collagen deposition. Data are presented as mean ± SD, n = 6. * P < 0.05 vs ND+SED and † P < 0.05 vs HFD+SED.