Research Paper Volume 13, Issue 8 pp 11061—11082

microRNA-363-3p reduces endothelial cell inflammatory responses in coronary heart disease via inactivation of the NOX4-dependent p38 MAPK axis

miR-363-3p reduces H2O2 level and CAT activity in CAECs by targeting NOX4. (A) quantification of H2O2 level in CAECs; (B) quantification of CAT activity in CAECs; the data were analyzed by one-way ANOVA with Tukey's post hoc test; n = 3; * p NOX4, NADPH oxidase 4; NC, negative control.

Figure 8. miR-363-3p reduces H2O2 level and CAT activity in CAECs by targeting NOX4. (A) quantification of H2O2 level in CAECs; (B) quantification of CAT activity in CAECs; the data were analyzed by one-way ANOVA with Tukey's post hoc test; n = 3; * p < 0.05 vs. the blank group; # p < 0.05 vs. the miR-363-3p mimic group; CAECs, coronary artery endothelial cells; CAT, catalase; miR, microRNA; NOX4, NADPH oxidase 4; NC, negative control.