Research Paper Volume 13, Issue 5 pp 6525—6553

Hypoxia associated multi-omics molecular landscape of tumor tissue in patients with hepatocellular carcinoma

Changes in functional proteomics between hepatocellular carcinoma (HCC) patients with high hypoxia scores and low hypoxia scores. (A) Fifty proteins with significant differences in abundance between HCC patients with high hypoxia scores and low hypoxia scores. (B) A schematic diagram of some proteins with significant differences in abundance in the AKT/mTOR pathway. (C) The low abundance of AKT, AKT-pT308, and AKT

Figure 5. Changes in functional proteomics between hepatocellular carcinoma (HCC) patients with high hypoxia scores and low hypoxia scores. (A) Fifty proteins with significant differences in abundance between HCC patients with high hypoxia scores and low hypoxia scores. (B) A schematic diagram of some proteins with significant differences in abundance in the AKT/mTOR pathway. (C) The low abundance of AKT, AKT-pT308, and AKT_pS473 proteins in TCGA-LIHC indicates poor overall survival.