Research Paper Volume 13, Issue 7 pp 9732—9747

Comprehensive multiomics analysis of the effect of ginsenoside Rb1 on hyperlipidemia

RB1 increase phosphatidylcholine in glycerophospholipid metabolism to prevent hyperlipidemia. Through multi-omics analysis, we found Glycerophospholipid metabolism was a common pathway between Rb1 and model group. By using germ-free mice, we found Rb1 increased the abundance of Turicibacter and decreased the abundance of Blautia and Allobaculum to increase content of phosphatidylcholine by raising Pemt and reducing Pla2g4b and Phospho1, and resulting the downregulation of total cholesterol to play a prevention role in hyperlipideamia. Notes: The green box in mocrobe and metabolism box represents the content reduced, the orange box represents the content increased. Pemt promotes synthesis of phosphatidylcholine, Pla2g4b and Phospho1 accelerate decomposition of phosphatidylcholine. Notes: Experiments were repeated twice, data was shown in mean +/- SD, * represent P

Figure 5. RB1 increase phosphatidylcholine in glycerophospholipid metabolism to prevent hyperlipidemia. Through multi-omics analysis, we found Glycerophospholipid metabolism was a common pathway between Rb1 and model group. By using germ-free mice, we found Rb1 increased the abundance of Turicibacter and decreased the abundance of Blautia and Allobaculum to increase content of phosphatidylcholine by raising Pemt and reducing Pla2g4b and Phospho1, and resulting the downregulation of total cholesterol to play a prevention role in hyperlipideamia. Notes: The green box in mocrobe and metabolism box represents the content reduced, the orange box represents the content increased. Pemt promotes synthesis of phosphatidylcholine, Pla2g4b and Phospho1 accelerate decomposition of phosphatidylcholine. Notes: Experiments were repeated twice, data was shown in mean +/- SD, * represent P<0.05, ** represent P<0.01, *** represent P<0.001.