Research Paper Volume 13, Issue 7 pp 9780—9800

Lung cancer-associated mesenchymal stem cells promote tumor metastasis and tumorigenesis by induction of epithelial–mesenchymal transition and stem-like reprogram

Identification of lung cancer-associated mesenchymal stem cells. (A) Tissue block culturing method was used to isolate MSCs from matched primary lung cancer and adjacent tumor-free tissues. Arrow, lung cancer tissue. (B) Adipogenic, osteogenic and chondrogenic differentiation was induced in MSCs in vitro. (C) The expression of surface markers of MSCs was tested by cytometry flow. (A–C) were representative results from LC-MSCs of one patient. LC-MSCs, lung cancer-associated mesenchymal stem cells.

Figure 1. Identification of lung cancer-associated mesenchymal stem cells. (A) Tissue block culturing method was used to isolate MSCs from matched primary lung cancer and adjacent tumor-free tissues. Arrow, lung cancer tissue. (B) Adipogenic, osteogenic and chondrogenic differentiation was induced in MSCs in vitro. (C) The expression of surface markers of MSCs was tested by cytometry flow. (AC) were representative results from LC-MSCs of one patient. LC-MSCs, lung cancer-associated mesenchymal stem cells.