**Figure 4.** **The lesion-based risk score using three radiomic features only.** GOH_Percentile_(15) represents the radiomic feature gradient orient histogram, which describes the percentiles of the occurrence probability values in the histogram of the image. The numbers in the brackets represent the parameters used to calculate that particular radiomic feature. The parameter of 15 in GOH_Percentile represents the histogram percentile. GLCM_Correlation_(25,0,1) represents the radiomic feature gray-level co-occurrence matrix with statistical measurement of correlation between a pixel and its neighbor over the whole image, which describes that the gray-level co-occurrence matrix was computed from the image inside the binary mask in 2.5D with the direction of the angle of intensity pair at 0 degrees and the distance between the intensity pairs at 1. ID-Local_Range_Std represents the intensity direct in the neighborhood region, which describes the standard deviation among all the voxels.