Research Paper Volume 13, Issue 5 pp 6375—6405

Oral administration of Akkermansia muciniphila elevates systemic antiaging and anticancer metabolites

Ileum, colon, liver, and plasma targeted metabolites relative abundance variations in mice treated with FMT or Akk at days 3, 7 and 14 after the first oral gavage. Hierarchical clustering (euclidean distance, ward linkage method) of the metabolite abundance is shown. Note that Supplementary Figures 6 to 9 provide the names of each of the metabolites, for each of the different matrices. The purpose of this figure is to allow for a direct comparison of the amplitude of the metabolic effects of manipulation of the microbiota. FMT, fecal microbiota transplant; Akk, Akkermansia muciniphila; FC, fold change.

Figure 3. Ileum, colon, liver, and plasma targeted metabolites relative abundance variations in mice treated with FMT or Akk at days 3, 7 and 14 after the first oral gavage. Hierarchical clustering (euclidean distance, ward linkage method) of the metabolite abundance is shown. Note that Supplementary Figures 6 to 9 provide the names of each of the metabolites, for each of the different matrices. The purpose of this figure is to allow for a direct comparison of the amplitude of the metabolic effects of manipulation of the microbiota. FMT, fecal microbiota transplant; Akk, Akkermansia muciniphila; FC, fold change.