Research Paper Volume 13, Issue 5 pp 6375—6405

Oral administration of Akkermansia muciniphila elevates systemic antiaging and anticancer metabolites

Differential metabolite identification in samples from ileum (A), or colon (B) from mice receiving FMT or Akk at day 3 after the first oral gavage. The horizontal dashed gray line shows where p=0.05 with points above being metabolites with significantly different relative abundance (pp value) are annotated. Families of metabolites are grouped by colors.

Figure 4. Differential metabolite identification in samples from ileum (A), or colon (B) from mice receiving FMT or Akk at day 3 after the first oral gavage. The horizontal dashed gray line shows where p=0.05 with points above being metabolites with significantly different relative abundance (p<0.05). The vertical dashed gray lines correspond to FC=1. Targeted metabolites that display both large magnitude FC and higher statistical difference (-log10 of p value) are annotated. Families of metabolites are grouped by colors.