Research Paper Volume 13, Issue 5 pp 6375—6405

Figure 6. Reduced picture of the untargeted metabolomics analysis illustrated in Figure 5, showing selected features which significantly increased after Akk or Akk-past oral gavage in the different extracted organs, compared to FMT, PBS, or continuous ATB. Each row represents a metabolite. Hierarchical clustering (euclidean distance, ward linkage method) of the metabolite abundance is shown. PBS, phosphate buffer saline; ATB, antibiotics; FMT, fecal microbiota transplant; Akk, Akkermansia muciniphila; Akk-past, pasteurized Akkermansia muciniphila; FC, fold change.