Research Paper Volume 13, Issue 5 pp 6298—6329

Calorie restriction prevents age-related changes in the intestinal microbiota

Analysis of colon mucosa transcriptome of C57BL/6JN mice fed AL and CR. (A) PCA analysis of transcriptome from adult and old mice fed AL or CR. (B) Heatmap of the relative levels of the transcripts that changed significantly with either age and/or CR in individual mice compared to Adult AL mice. The data were collected from 4 mice per group, and the PCA and heatmap plots show 94 transcripts that show 2-fold change in expression [P (Corr)

Figure 10. Analysis of colon mucosa transcriptome of C57BL/6JN mice fed AL and CR. (A) PCA analysis of transcriptome from adult and old mice fed AL or CR. (B) Heatmap of the relative levels of the transcripts that changed significantly with either age and/or CR in individual mice compared to Adult AL mice. The data were collected from 4 mice per group, and the PCA and heatmap plots show 94 transcripts that show 2-fold change in expression [P (Corr) <=0.05)].