Research Paper Volume 13, Issue 5 pp 6298—6329

Calorie restriction prevents age-related changes in the intestinal microbiota

Effect of age and CR on the fecal metabolome. (A) Venn diagram showing the distribution of the number of metabolites that changed significantly in C57BL/6JN mice with age (orange) or with CR in old C57BL/6JN mice (blue) or changed significantly with CR in B6D2F1 mice (green). (B) PCA Analysis of fecal metabolites from adult and old C57BL/6JN mice fed AL or CR (6 mice/group). Data normalized and imputed from the 98 metabolites. (C) PCA Analysis of fecal metabolites from old AL and CR C57BL/6JN and B6D2F1 mice (6 mice/group) normalized and imputed from the 98 metabolites.

Figure 7. Effect of age and CR on the fecal metabolome. (A) Venn diagram showing the distribution of the number of metabolites that changed significantly in C57BL/6JN mice with age (orange) or with CR in old C57BL/6JN mice (blue) or changed significantly with CR in B6D2F1 mice (green). (B) PCA Analysis of fecal metabolites from adult and old C57BL/6JN mice fed AL or CR (6 mice/group). Data normalized and imputed from the 98 metabolites. (C) PCA Analysis of fecal metabolites from old AL and CR C57BL/6JN and B6D2F1 mice (6 mice/group) normalized and imputed from the 98 metabolites.