Research Paper Volume 13, Issue 5 pp 6420—6441

Aging and pathological aging signatures of the brain: through the focusing lens of SIRT6

SIRT6 deletion affects gene expression in the brain. (A) Experimental design: RNA was isolated from the brains of three SIRT6-KO mice, three age-matched WT mice (21 days), and three old WT mice (22-26 months). (B) Hierarchical clustering of samples. Colors represent Pearson correlation coefficients. (C) Expression levels of genes identified as upregulated or downregulated in a comparison between SIRT6-KO and young WT mice. Red color corresponds to increased expression, while blue color corresponds to decreased expression. (D) Expression levels of genes identified as upregulated or downregulated in a pool of SIRT6-KO and old WT mice compared to young WT mice. Colors are as in (C).

Figure 1. SIRT6 deletion affects gene expression in the brain. (A) Experimental design: RNA was isolated from the brains of three SIRT6-KO mice, three age-matched WT mice (21 days), and three old WT mice (22-26 months). (B) Hierarchical clustering of samples. Colors represent Pearson correlation coefficients. (C) Expression levels of genes identified as upregulated or downregulated in a comparison between SIRT6-KO and young WT mice. Red color corresponds to increased expression, while blue color corresponds to decreased expression. (D) Expression levels of genes identified as upregulated or downregulated in a pool of SIRT6-KO and old WT mice compared to young WT mice. Colors are as in (C).