Research Paper Volume 13, Issue 7 pp 10034—10057

A five-m6A regulatory gene signature is a prognostic biomarker in lung adenocarcinoma patients

Gene enrichment analysis in the turquoise module and determination of hub genes in the PPI network. (A) GO enrichment analysis of genes in the turquoise module. (B) KEGG pathway enrichment analysis of genes in the turquoise module. (C) Correlation analysis of genes in the turquoise module and the risk score. The cutoff values were set as gene significance (GS) > 0.55 and module membership (MM) > 0.85. (D) PPI network of all genes in the turquoise module including top 15 hub genes with the highest degree. PPI network was constructed using the STRING database and the Cytoscape software. (E) Venn diagram shows six common genes in the three lists of candidate hub genes. (F) The forest plot shows association between expression levels of the six hub genes and the OS status of LADC patients as assessed by the univariate Cox regression model.

Figure 8. Gene enrichment analysis in the turquoise module and determination of hub genes in the PPI network. (A) GO enrichment analysis of genes in the turquoise module. (B) KEGG pathway enrichment analysis of genes in the turquoise module. (C) Correlation analysis of genes in the turquoise module and the risk score. The cutoff values were set as gene significance (GS) > 0.55 and module membership (MM) > 0.85. (D) PPI network of all genes in the turquoise module including top 15 hub genes with the highest degree. PPI network was constructed using the STRING database and the Cytoscape software. (E) Venn diagram shows six common genes in the three lists of candidate hub genes. (F) The forest plot shows association between expression levels of the six hub genes and the OS status of LADC patients as assessed by the univariate Cox regression model.