Research Paper Volume 13, Issue 7 pp 10058—10074

Gut microbiota from mice with cerebral ischemia-reperfusion injury affects the brain in healthy mice

Effect of BCCAO microbiota on hippocampal neuroinflammation. (A) Levels of G-CSF, GM-CSF, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-17, IFNγ, IP-10, TNF-α, RANTES, MCP-1, eotaxin, and MIP-1β in the hippocampus of micecontrol and miceBCCAO. (B) PCA of the data from multiplex bead analysis; each dot represents one mouse. (C) Mean PCA scores of mice with and without BCCAO microbiota. *, P P P t-tests or a two-way repeated-measures ANOVA with post-hoc Tukey multiple comparisons test. All values are expressed as means ± S.D; n=15.

Figure 6. Effect of BCCAO microbiota on hippocampal neuroinflammation. (A) Levels of G-CSF, GM-CSF, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-17, IFNγ, IP-10, TNF-α, RANTES, MCP-1, eotaxin, and MIP-1β in the hippocampus of micecontrol and miceBCCAO. (B) PCA of the data from multiplex bead analysis; each dot represents one mouse. (C) Mean PCA scores of mice with and without BCCAO microbiota. *, P < 0.05; **, P < 0.01; and ***, P < 0.001 compared with control mice using unpaired Student`s t-tests or a two-way repeated-measures ANOVA with post-hoc Tukey multiple comparisons test. All values are expressed as means ± S.D; n=15.