Figure 6. The genetic features of ITIH1 in pan-cancers. (A) Genetic alteration frequencies of ITIH1 across different tumors from TCGA. (B) The mutation type and mutation site as determined by cBioportal. (C) Correlation between ITIH1 mRNA expression and mutation levels of five key MMR genes (MLH1, MSH2, MSH6, PMS2, EPCAM). The lower triangle in each tile indicates coefficients calculated by Pearson’s correlation test, and the upper triangle indicates log10 transformed P-value. *P < 0.05; **P < 0.01; ***P < 0.001.