Research Paper Volume 13, Issue 5 pp 6442—6458

Male-specific age estimation based on Y-chromosomal DNA methylation

Male-specific epigenetic age prediction in blood based on 75 Y-CpGs using support vector machine (radial kernel). Validation dataset (n = 172): (A) Predicted vs. true age and (B) age prediction errors per age category; Testing dataset (n = 127): (C) Predicted vs. true age and (D) age prediction errors per age category. ρ: Spearman correlation coefficient, RMSE: root mean square error, MAD: mean absolute deviation.

Figure 3. Male-specific epigenetic age prediction in blood based on 75 Y-CpGs using support vector machine (radial kernel). Validation dataset (n = 172): (A) Predicted vs. true age and (B) age prediction errors per age category; Testing dataset (n = 127): (C) Predicted vs. true age and (D) age prediction errors per age category. ρ: Spearman correlation coefficient, RMSE: root mean square error, MAD: mean absolute deviation.