Research Paper Volume 13, Issue 8 pp 11150—11169

The neuroprotection of deproteinized calf blood extractives injection against Alzheimer's disease via regulation of Nrf-2 signaling

DCBEI attenuates pathology in the brains of APP/PS1 mice. DCBEI (A) reduced the expression of Aβ1-42 in the hippocampus (n = 10), and (B) increased the levels of Aβ1-42 in the serum (n = 10). Data are expressed as means ± S.D. (n = 10). # P P P P C) DCBEI reduced the level of Aβ in the hippocampus (n = 3). (D) DCBEI attenuated the increase in p-Tau levels in the hippocampus (n = 3), (E) but did not affect the levels of total Tau (n = 3). (F) DCBEI significantly reduced the levels of 4-HNE in the brains of APP/PS1 mice (n = 3) (40×) (Scale bar: 200 μm) (200×) (Scale bar: 50 μm). (G) TUNEL staining shows that a 28-day course of DCBEI significantly reduces apoptosis (n = 3) (200×) (Scale bar: 50 μm).

Figure 4. DCBEI attenuates pathology in the brains of APP/PS1 mice. DCBEI (A) reduced the expression of Aβ1-42 in the hippocampus (n = 10), and (B) increased the levels of Aβ1-42 in the serum (n = 10). Data are expressed as means ± S.D. (n = 10). # P < 0.05 and ## P < 0.01 vs. WT, * P < 0.05 and ** P < 0.01 vs. APP/PS1 mice. (C) DCBEI reduced the level of Aβ in the hippocampus (n = 3). (D) DCBEI attenuated the increase in p-Tau levels in the hippocampus (n = 3), (E) but did not affect the levels of total Tau (n = 3). (F) DCBEI significantly reduced the levels of 4-HNE in the brains of APP/PS1 mice (n = 3) (40×) (Scale bar: 200 μm) (200×) (Scale bar: 50 μm). (G) TUNEL staining shows that a 28-day course of DCBEI significantly reduces apoptosis (n = 3) (200×) (Scale bar: 50 μm).