Research Paper Volume 13, Issue 8 pp 11150—11169

The neuroprotection of deproteinized calf blood extractives injection against Alzheimer's disease via regulation of Nrf-2 signaling

Proteomic and metabonomic profiling of the effects of DCBEI in APP/PS1 mice. (A) Heat map of differentially expressed factors (n = 3). (B) The relationship between proteins processed through STRINGdb. (C) Serum neurotransmitter levels were quantified using HPLC-MS/MS. Significant differences in the levels of nine neurotransmitters (R-amino-butyric acid, norepinephrine, 5-HIAA, serotonin, methoxytyramine, histamine, tyramine, glutamine and normetanephrine) was observed (n = 3).

Figure 5. Proteomic and metabonomic profiling of the effects of DCBEI in APP/PS1 mice. (A) Heat map of differentially expressed factors (n = 3). (B) The relationship between proteins processed through STRINGdb. (C) Serum neurotransmitter levels were quantified using HPLC-MS/MS. Significant differences in the levels of nine neurotransmitters (R-amino-butyric acid, norepinephrine, 5-HIAA, serotonin, methoxytyramine, histamine, tyramine, glutamine and normetanephrine) was observed (n = 3).