Figure 2. Influences of maternal high sugar and fat diet on autophagy and neurodevelopment of offspring during the growth stage. (A) Changes on the body weight; (B) Changes on inflammatory factors in serum; (C) the marked proteins expression of KGA/GAD, MAP2, GFAP, Vimentin, IBA1, GAD65, DYNC1H1, Myclin, Tubulin, CHAT, OLIG2 and WFS1 in brain tissues, (D) and the expression LC3A I/LC3A II/ LC3B I/LC3B II protein in brain tissues. The symbol of NA is the 16-month control male samples, NB is the 16-month control female samples; MA is the 16-month HSHF male samples, MB is the 16-month HSHF female samples. Data are presented as the means ± SD of more than 8 independent experiments, and more than 3 independent experiments in Western bolting. *p <0.05 and **p <0.01 vs. the model group by one-way ANOVA, followed by the one-way analysis of variance (ANOVA) at p < 0.05.