Research Paper Volume 13, Issue 8 pp 11207—11217

Panax notoginseng protects the rat brain function from traumatic brain injury by inhibiting autophagy via mammalian targeting of rapamycin

Compared with the sham group, brain tissue and brain function of rats with traumatic brain injury were significantly damaged and autophagy was enhanced. (A) HE staining, Nissl staining and transmission electron microscopy of brain tissue. (B) The neural function defect score at 12h, 24h and 72h. (C) mTOR, p-mTOR, P62, Beclin 1, LC3I and LC3II by Western-blotting. n=6.

Figure 1. Compared with the sham group, brain tissue and brain function of rats with traumatic brain injury were significantly damaged and autophagy was enhanced. (A) HE staining, Nissl staining and transmission electron microscopy of brain tissue. (B) The neural function defect score at 12h, 24h and 72h. (C) mTOR, p-mTOR, P62, Beclin 1, LC3I and LC3II by Western-blotting. n=6.