Research Paper Volume 13, Issue 8 pp 11207—11217

Panax notoginseng protects the rat brain function from traumatic brain injury by inhibiting autophagy via mammalian targeting of rapamycin

Compared with the Rapamycin group, the brain tissue and brain function damages were improved, and autophagy protein was significantly decreased in the Panax notoginseng group and Panax notoginseng+Rapamycin group. (A) HE staining, Nissl staining and transmission electron microscopy of brain tissue. (B) The neural function defect score at 12h, 24h and 72h. (C) mTOR, p-mTOR, P62, Beclinl, LC31 and LC3ll by Western-blotting. n=6.

Figure 4. Compared with the Rapamycin group, the brain tissue and brain function damages were improved, and autophagy protein was significantly decreased in the Panax notoginseng group and Panax notoginseng+Rapamycin group. (A) HE staining, Nissl staining and transmission electron microscopy of brain tissue. (B) The neural function defect score at 12h, 24h and 72h. (C) mTOR, p-mTOR, P62, Beclinl, LC31 and LC3ll by Western-blotting. n=6.