Research Paper Volume 13, Issue 8 pp 11207—11217

Panax notoginseng protects the rat brain function from traumatic brain injury by inhibiting autophagy via mammalian targeting of rapamycin

Compared with the Panax notoginseng group, there was no significant difference in brain tissue destruction, brain function damage, while mTOR and p-mTOR were significantly decreased in the Panax notoginseng+Rapamycin group. (A) HE staining, Nissl staining and transmission electron microscopy of brain tissue. (B) The neural function defect score at 12h, 24h and 72h. (C) mTOR, p-mTOR, P62, Beclinl, LC3I and LC3II by Western-blotting. n=6.

Figure 5. Compared with the Panax notoginseng group, there was no significant difference in brain tissue destruction, brain function damage, while mTOR and p-mTOR were significantly decreased in the Panax notoginseng+Rapamycin group. (A) HE staining, Nissl staining and transmission electron microscopy of brain tissue. (B) The neural function defect score at 12h, 24h and 72h. (C) mTOR, p-mTOR, P62, Beclinl, LC3I and LC3II by Western-blotting. n=6.