Research Paper Volume 13, Issue 7 pp 10275—10288

CircRNA hsa_circ_0006215 promotes osteogenic differentiation of BMSCs and enhances osteogenesis–angiogenesis coupling by competitively binding to miR-942-5p and regulating RUNX2 and VEGF

CircRNA hsa

Figure 5. CircRNA hsa_circ_0006215 promotes BMSCs osteogenesis and bone regeneration in vivo. (A) Heterotopic osteogenic differentiation of BMSCs detected by HE staining. (B) New bone formation in cortical bone defect determined using MicroCT. MicroCT parameters (C) BV/TV and (D) BMD. All values are expressed as means ± SD of five samples. *p < 0.05, **p < 0.01. BMD, bone mineral density; BMSCs, bone marrow mesenchymal stem cells; BV/TV, bone volume per tissue volume; MicroCT, microcomputed tomography.