Research Paper Volume 13, Issue 7 pp 10312—10325

Membrane-cytoplasm translocation of annexin A4 is involved in the metastasis of colorectal carcinoma

ANXA4 downregulated the stromal response in CRC. (A) Common molecular function and biological process enrichment terms of ANXA4 determined by GO analysis. (B) Negative correlation analysis between ANXA4 and the stromal score. (C) Effects of ANXA4 overexpression on the EMT-related molecules E-cadherin, Vimentin, β-catenin and Snail. GAPDH was used as the loading control for total protein. (D, E) Relative quantitative analysis of E-cadherin, Vimentin, β-catenin and Snail expression in HT-29 cells (D) and SW620 cells (E). *p

Figure 6. ANXA4 downregulated the stromal response in CRC. (A) Common molecular function and biological process enrichment terms of ANXA4 determined by GO analysis. (B) Negative correlation analysis between ANXA4 and the stromal score. (C) Effects of ANXA4 overexpression on the EMT-related molecules E-cadherin, Vimentin, β-catenin and Snail. GAPDH was used as the loading control for total protein. (D, E) Relative quantitative analysis of E-cadherin, Vimentin, β-catenin and Snail expression in HT-29 cells (D) and SW620 cells (E). *p < 0.05; **p < 0.01; ***p < 0.001.